Development and validation of two redox-related genes associated with prognosis and immune microenvironment in endometrial carcinoma

In recent studies, the tumourigenesis and development of endometrial carcinoma (EC) have been correlated significantly with redox.We aimed to develop and validate a redox-related prognostic model of patients with EC to predict the prognosis and the efficacy of immunotherapy.We downloaded gene expression Magnetic Contact Switch profiles and clinical

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Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction

Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients.Unfortunately, an unintended consequence of prolonged MV is the rapid development of diaphragmatic atrophy and contractile dysfunction, known as ventilator-induced diaphragm dysfunction (VIDD).Although the mechanism(s) responsible for VIDD are not fully under

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Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation

Abstract The extracellular matrix plays a key role in cancer progression.Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes.Hyaluronan acts through the interaction with cell membrane receptors as CD44 and RHAMM and triggers signaling pathways as MEK/ERK.4-methylumbelliferone (4MU), a well

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